Issue 6, 2016
From the journal:

RSC Advances

3-Methylene-2,4-chromandione in situ trapping: introducing molecular diversity on 4-hydroxycoumarin†

Adrien Montagut-Romans,a   Manon Boulven,a   Marc Lemairea  and  Florence Popowycz*a  

* Corresponding authors

a Equipe Chimie Organique et Bioorganique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Institut National des Sciences Appliquées (INSA Lyon), Bâtiment Jules Verne, 20 Avenue Albert Einstein, F-69621 Villeurbanne Cedex, France
E-mail: florence.popowycz@insa-lyon.fr
Fax: +33 4 72 43 88 96
Tel: +33 4 72 43 82 21

Abstract

3-Methylene-2,4-chromandione trapped in a solid-state stable Mannich adduct, is released in solution. In the presence of different nucleophiles, this highly reactive intermediate allows the introduction of molecular diversity on C-3 position of 4-hydroxycoumarin.

Graphical abstract: 3-Methylene-2,4-chromandione in situ trapping: introducing molecular diversity on 4-hydroxycoumarin

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Article information

DOI
https://doi.org/10.1039/C5RA22440C
Article type
Communication
Submitted
26 Oct 2015
Accepted
25 Nov 2015
First published
26 Nov 2015

RSC Adv., 2016,6, 4540-4544

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3-Methylene-2,4-chromandione in situ trapping: introducing molecular diversity on 4-hydroxycoumarin

A. Montagut-Romans, M. Boulven, M. Lemaire and F. Popowycz, RSC Adv., 2016, 6, 4540 DOI: 10.1039/C5RA22440C

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