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Domino reactions

More than just a game

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Catalytic methods are among the most valuable tools for sustainable synthesis. Domino catalysis enables multiple reactions to be combined so that synthetic efficiency may begin to approach that of nature, but significant challenges remain before this promising approach can fulfil the needs of pharmaceutical and materials chemistry.

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Figure 1: Examples of organocatalysed domino processes.

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Correspondence to Kirsten Zeitler.

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Broja, T., Fuchs, P. & Zeitler, K. More than just a game. Nature Chem 7, 950–951 (2015). https://doi.org/10.1038/nchem.2402

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